Selenium Supplementation Reduced Oxidative Stress in Diethylnitrosamine-induced Hepatocellular Carcinoma in Rats

Liver transplantation for diethylnitrosamine-induced hepatocellular carcinoma in rats.

H UMAN hepatocellular carcinoma (HCC) is a highly malignant tumor with a natural history of a few months from the time of diagnosis. Curative resection offers the best chance of survival. l However, surgical resectability rates rarely exceed 30% to 40% because of extensiveness of the tumors or because coexisting liver disease precludes attempted partial hepatectomy.2 Consequently, total liver r...

Calcium Supplementation Ameliorates Cerebellar Oxidative Stress in Lactational Aluminum-induced Neurotoxicity in Rats

Introduction: The neurotoxic effects of aluminum exposure during the critical period of neurodevelopment have been well documented. This study investigated the known protective effects of calcium supplementation on the cerebellum of juvenile Wistar rats following aluminum-induced neurotoxicity during lactation. Methods: Four groups of juvenile rats were exposed via lactation to distilled water...

Protective effect of Cassia fistula Linn. on diethylnitrosamine induced hepatocellular damage and oxidative stress in ethanol pretreated rats.

Diethylnitrosamine (DEN), found in many commonly consumed foods, is widely reported to induce cancer in animals and humans. The aim of the present study was to investigate the hepatoprotective and antioxidant activities of the leaf extract of the medicinal plant Cassia fistula Linn. against diethylnitrosamine induced liver injury in ethanol pretreated rats. Albino Wistar rats, pretreated with e...

Pharmacokinetics and tissue distribution study of caudatin in normal and diethylnitrosamine-induced hepatocellular carcinoma model rats.

Caudatin is a potential antitumor agent isolated from the traditional Chinese medicine "baishouwu", which was the root tuber of Cynanchum auriculatum Royle ex Wight. In our previous studies, caudatin showed selectivity on human hepatoma cell line SMMC7721 among several different tumor cell lines, and further in vivo tests validated the inhibitory action of caudatin against hepatic cancer using ...

Hepatocellular Carcinoma in Sheep